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October 1, 2024Diabetes Metabolic Syndrome and ObesityOpen Access

Liraglutide significantly reduced blood glucose, serum creatinine, blood urea nitrogen, and urinary protein levels, while suppressing markers of endothelial injury and the Dll4/Notch2 signaling pathway (all P < 0.05).

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Why the study?

GLP-1 receptor agonists have renoprotective effects, but the impact of liraglutide on early endothelial dysfunction in diabetic rats and its underlying mechanisms needed investigation.

Does liraglutide improve early endothelial dysfunction in diabetic rats?

Population

Diabetic rat model induced by high-fat, high-sugar diet and streptozotocin

Comparison

Liraglutide at various doses vs untreated diabetic kidney disease rats

Design

Animal experimental study

Authors

YLYining LiYCYulin ChenHZHui Zhang

Discussion

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Overview

Hypothesis-generating in diabetic rats; leaves open translation to human endothelial dysfunction.

Structured PICO

Does liraglutide improve early endothelial dysfunction in diabetic rats?

P
Population
Experimental rat model of diabetes established using a high-fat, high-sugar diet in combination with a single intraperitoneal injection of streptozotocin (STZ)
I
Intervention
Liraglutide (various doses)
C
Comparator
Untreated diabetic kidney disease (DKD) rats
O
Outcome
Renal injury and early endothelial dysfunction (measured by blood glucose, serum creatinine, blood urea nitrogen, urinary protein levels, and expression of endothelial injury markers)surrogate

Liraglutide ameliorates renal endothelial dysfunction and reduces urinary protein excretion in diabetic rats, likely through the inhibition of the Dll4/Notch2 signaling pathway.

Cite This Study

Li et al. (2024) studied this question.

synapsesocial.com/papers/6a8cebacb757b13449eaa307https://doi.org/10.2147/dmso.s492252
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Liraglutide ameliorates inflammation and fibrosis by downregulating the TLR4/MyD88/NF-kappaB pathway in diabetic kidney disease2024 · 8 citations
  2. 2Liraglutide protects cardiac function in diabetic rats through the PPARα pathway2018 · 35 citations
  3. 3Liraglutide Inhibits Endothelial-to-Mesenchymal Transition and Attenuates Neointima Formation after Endovascular Injury in Streptozotocin-Induced Diabetic Mice2019 · 38 citations
  4. 4Liraglutide Attenuates Diabetic Cardiomyopathy via the ILK/PI3K/AKT/PTEN Signaling Pathway in Rats with Streptozotocin-Induced Type 2 Diabetes Mellitus2024 · 10 citations
  5. 5Exploration on the protective effect of liraglutide on renal injury in diabetic nephropathy rats based on ROS-NLRP3 inflammasomes2024