Population
Vascular smooth muscle from different arteries of the rabbit
Design
Preclinical
Authors
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Agonist affinity may primarily govern norepinephrine sensitivity in animal vessels; leaves open receptor reserve relevance and human translation.
Agonist affinity appears to be the primary determinant of sensitivity to norepinephrine in rabbit arteries, suggesting a locally regulated mechanism for regional sensitivity changes.
Bevan et al. (1986) studied this question.
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