Population
Anesthetized, normotensive rats and pithed, normotensive rats
Design
Preclinical
Authors
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May indicate identical central/peripheral alpha-adrenoceptor agonist demands in animals; leaves open human translation.
Central and peripheral alpha-adrenoceptors exhibit identical demands upon their agonists when accounting for differences in accessibility via lipophilicity.
Timmermans et al. (1981) studied this question.
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