Key result
Chemical sympathectomy significantly reduced vasopressor responses to phenylephrine but not 5-HT, while adrenal demedullation caused a slight reduction in sensitivity to all agonists in pithed rats.
Population
Pithed rats
Comparison
Chemical sympathectomy or bilateral adrenal… vs Untreated rats
Design
Preclinical
Authors
Loading...
Offers no basis to alter vasopressor strategies clinically; leaves open whether sympathectomy shifts vascular adrenoreceptor balance in intact models.
Circulating adrenal medullary catecholamines do not physiologically modulate vascular alpha-adrenoreceptor function, but chemical sympathectomy may alter the ratio of innervated vascular alpha-2 to alpha-1 adrenoreceptors.
Baker et al. (1981) studied this question. Chemical sympathectomy or bilateral adrenal demedullation vs. Untreated rats was evaluated on Vasopressor responses to phenylephrine and M-7. Chemical sympathectomy significantly reduced vasopressor responses to phenylephrine but not 5-HT, while adrenal demedullation caused a slight reduction in sensitivity to all agonists in pithed rats.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: