Population
Primary rat embryonic cortical neurons (in vitro) and adult mouse brain (in vivo)
Comparison
Adeno-associated virus (AAV) serotypes 1, 8, and 9 vs Comparison among AAV serotypes 1, 8, and 9
Design
Preclinical
Authors
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May guide AAV serotype selection via uptake enhancement in gene therapy; leaves open translation to human cardiovascular applications.
Variability in distal transduction of AAV serotypes in vivo likely results from differential uptake at the plasma membrane rather than fundamental differences in transport mechanisms.
Castle et al. (2014) studied this question.
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