What question did this study set out to answer?

To characterize the clinical progression and histologic manifestations of nephrotoxicity associated with long-term ciclosporin therapy in autoimmune uveitis.

October 28, 2008American Journal of Nephrology

Evolution of Ciclosporin Nephrotoxicity in Patients Treated for Autoimmune Uveitis

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Authors

HAHoward A. AustinUniversity of Southern California APAlan G. PalestineUniversity of Colorado System SSSharda G. SabnisSmithsonian Institution

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Implication

Cohort study reveals progressive renal scarring despite stable kidney function in ciclosporin-treated autoimmune uveitis, highlighting risks of occult long-term nephrotoxicity.

Key Points

To characterize the clinical progression and histologic manifestations of nephrotoxicity associated with long-term ciclosporin therapy in autoimmune uveitis.
Monitored renal function in 73 patients receiving ciclosporin for autoimmune uveitis to identify serum creatinine elevations of at least 50%.
Performed sequential inulin clearance measurements and serial renal biopsies in a subset of 17 patients to evaluate functional and structural changes following dosage adjustments.
A 50% elevation in serum creatinine occurred in 37% of patients within 3 months of initiation and in 25% after more than 6 months of therapy.
Inulin clearance remained stable in 12 patients, declined in 3 patients, and more than doubled following dosage reduction in 2 patients.
Follow-up biopsies demonstrated an increased chronicity index (glomerular sclerosis, tubular atrophy, interstitial fibrosis) in 3 of 6 patients, with arteriolar hyaline change present in all treated patients.

Cite This Study

Austin et al. (2008) studied this question.

synapsesocial.com/papers/6a8cf8c1a0da40c23df557ae https://doi.org/10.1159/000168001

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Implication

Cohort study reveals progressive renal scarring despite stable kidney function in ciclosporin-treated autoimmune uveitis, highlighting risks of occult long-term nephrotoxicity.

Evolution of Ciclosporin Nephrotoxicity in Patients Treated for Autoimmune Uveitis

Discussion

Member takes

Implication

Key Points

Cite This Study

Evolution of Ciclosporin Nephrotoxicity in Patients Treated for Autoimmune Uveitis

Discussion

Member takes

Implication

Key Points

Cite This Study

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