Why the study?
Does concomitant moderate-severe mitral regurgitation increase mortality in patients undergoing TAVR, and does valve type influence MR improvement?
Population
8,015 patients with aortic stenosis undergoing transcatheter aortic valve replacement pooled from 8 national…
Comparison
Presence of moderate-severe mitral regurgitation… vs Absence of significant MR; SEV vs BEV.
Design
Meta-analysis
Follow-up
30 days and 1 year for mortality; median 180 days for MR…
Authors
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Concomitant significant MR increases post-TAVR mortality; extends evidence that balloon-expandable valves enhance MR improvement and informs valve selection.
Does concomitant moderate-severe mitral regurgitation increase mortality in patients undergoing TAVR, and does valve type influence MR improvement?
Concomitant moderate-severe MR increases early and late mortality after TAVR, though MR severity improves in about half of patients, particularly those receiving balloon-expandable valves.
Nombela‐Franco et al. (2015) studied this question.
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