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November 1, 1997Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

Antibodies Against Cardiolipin and Oxidatively Modified LDL in 50-Year-Old Men Predict Myocardial Infarction

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Why the study?

Do raised levels of antibodies against oxLDL and cardiolipin predict myocardial infarction and MI-related death in healthy 50-year-old men?

Population

Healthy 50-year-old men

Design

Case-control

Follow-up

20 years

Authors

RWRuihua WuThe People's Hospital of Guangxi Zhuang Autonomous RegionSNSoniya NityanandSanjay Gandhi Post Graduate Institute of Medical SciencesLBLars BerglundDalarna University

Discussion

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Implication

Should not yet change risk assessment in midlife men; hypothesis-generating for antibody-based MI prediction.

Structured PICO

Do raised levels of antibodies against oxLDL and cardiolipin predict myocardial infarction and MI-related death in healthy 50-year-old men?

P
Population
Healthy 50-year-old men
I
Intervention
Raised levels of antibodies against oxidatively modified low-density lipoproteins (oxLDL) and cardiolipin
O
Outcome
Incidence of myocardial infarction (MI) and mortality related to MIhard clinical

Raised levels of antibodies against oxLDL and cardiolipin in healthy 50-year-old men are strong, independent predictors of future myocardial infarction and MI-related death.

Cite This Study

Wu et al. (1997) studied this question.

synapsesocial.com/papers/6a8cfafc2fc7b5a11ff55a82https://doi.org/10.1161/01.atv.17.11.3159
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Anticardiolipin antibodies in ischaemic heart disease: marker or myth?1993 · 67 citations
  2. 2The Second International Anti-Cardiolipin Standardization Workshop/The Kingston Anti-Phospholipid Antibody Study (KAPS) Group1990 · 416 citations
  3. 3Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H).1990 · 1,614 citations
  4. 4Patients With Early-Onset Peripheral Vascular Disease Have Increased Levels of Autoantibodies Against Oxidized LDL1995 · 281 citations
  5. 5Autoantibodies against oxidized low density lipoproteins (oxLDL): characterization of antibody isotype, subclass, affinity and effect on the macrophage uptake of oxLDL1995 · 94 citations