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September 21, 2020European Journal of PediatricsOpen Access

Mean Z-scores for LMCA, RMCA, and LAD increased significantly between the initial (LMCA 0.79z, RMCA 0.15z, LAD 0.49z) and second (LMCA 1.69z, RMCA 0.99z, LAD 1.69z) examination (p < 0.05).

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Why the study?

Up to 25% of untreated Kawasaki disease patients develop coronary artery complications, making early diagnosis and treatment essential, particularly in incomplete KD.

Does serial echocardiography aid in the early diagnosis of Kawasaki disease by detecting coronary artery enlargement?

Population

94 patients diagnosed with KD at University Children's Hospital Regensburg

Comparison

Coronary artery Z-scores on initial vs second 2D-echocardiography

Design

Single-center retrospective cohort study

Authors

MHMaria HörlHMHolger MichelSDStephan Döring

Discussion

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Overview

Serial Z-score monitoring may aid incomplete KD diagnosis; leaves open need for prospective validation before guiding practice.

Structured PICO

Does serial echocardiography aid in the early diagnosis of Kawasaki disease by detecting coronary artery enlargement?

P
Population
94 children diagnosed with Kawasaki disease (33% with incomplete KD) at a single center in Germany between 2002 and 2018.
I
Intervention
Serial 2D-echocardiography to assess luminal diameters of coronary arteries normalized as Z-scores
O
Outcome
Change in Z-scores for the left main coronary artery (LMCA), right main coronary artery (RMCA), and left anterior descending artery (LAD) between initial and second examinationsurrogate

Serial echocardiography can detect significant progression of coronary artery Z-scores in Kawasaki disease, aiding early diagnosis even when initial Z-scores are within the normal range.

Cite This Study

Hörl et al. (2020) studied this question.

synapsesocial.com/papers/6a8cfb3758db4b48d89682cbhttps://doi.org/10.1007/s00431-020-03752-y
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The role of echocardiography in Kawasaki disease2017 · 60 citations
  2. 2Recent updates on echocardiography and ultrasound for Kawasaki disease: beyond the coronary artery2018 · 8 citations
  3. 3Echocardiographic Evaluation in Kawasaki Disease2025
  4. 4Cardiopulmonary Function, Exercise Capacity, and Echocardiography Finding of Pediatric Patients With Kawasaki Disease2016 · 18 citations
  5. 5Serial Exercise Testing and Echocardiography Findings of Patients With Kawasaki Disease2022 · 9 citations