Why the study?
Kawasaki disease is the most common pediatric vasculitis, but its influence on cardiopulmonary function and echocardiographic findings from childhood to adolescence required evaluation through serial follow-ups.
Does a history of Kawasaki disease reduce cardiopulmonary function in adolescence compared to healthy peers?
Population
30 patients with Kawasaki disease after the acute stage and 30 matched healthy controls
Comparison
Patients with Kawasaki disease vs age-, sex-, and body mass index-matched healthy peers
Design
Retrospective study
Key result
Adolescents with a history of Kawasaki disease had significantly lower peak oxygen consumption (76.17% vs 92.23% of predicted, p=0.0004) compared to healthy matched controls at final follow-up.
Authors
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Serial CPET/echo in KD may show evolving function; hypothesis-generating and leaves open need for prospective confirmation.
Cohort (n=60)
No
Does a history of Kawasaki disease reduce cardiopulmonary function in adolescence compared to healthy peers?
Absolute Event Rate: 76.17% vs 92.23%
p-value: p=0.0004
While children with a history of Kawasaki disease have comparable exercise capacity to healthy peers initially, their aerobic metabolism and peak exercise load capacities become significantly lower by adolescence.
Lin et al. (2022) conducted a cohort in Kawasaki disease (n=60). History of Kawasaki disease vs. Healthy matched controls was evaluated on Percentage of measured peak oxygen consumption (Vo2) to the predicted peak Vo2 at final follow-up (p=0.0004). Adolescents with a history of Kawasaki disease had significantly lower peak oxygen consumption (76.17% vs 92.23% of predicted, p=0.0004) compared to healthy matched controls at final follow-up.
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