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January 1, 2025ClinicsOpen Access

Impaired cardiopulmonary functions in prepubertal patients with Kawasaki disease

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Why the study?

This study was conducted to investigate cardiopulmonary function in prepubertal patients with Kawasaki disease compared with healthy controls.

Does a history of Kawasaki disease impair cardiopulmonary function in prepubertal children compared to healthy controls?

Population

117 Kawasaki disease patients and 121 matched controls aged 8 to 12 years in Taiwan

Comparison

Patients with a history of Kawasaki disease vs healthy controls

Design

Two-center retrospective cohort study

Authors

YLYen‐Sen LuIHI‐Ching HuangYWYen-Hsien Wu

Discussion

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Overview

Reduced aerobic capacity in prepubertal KD children, worse in males, supports safe activity; leaves open exercise benefits for prospective trials.

Structured PICO

Does a history of Kawasaki disease impair cardiopulmonary function in prepubertal children compared to healthy controls?

P
Population
238 prepubertal children aged 8 to 12 years, including 117 with a history of Kawasaki Disease (mean age 9.64 ± 1.66 years, 58.1% male) and 121 healthy controls (mean age 9.72 ± 1.66 years, 58.7% male) from two medical centers in Taiwan.
I
Intervention
History of Kawasaki Disease
C
Comparator
Age-, sex-, and body mass index-matched healthy controls
O
Outcome
Cardiopulmonary function (aerobic capacity and peak exercise tolerance) measured by Cardiopulmonary Exercise Test (CPET) and pulmonary function testsurrogate

Prepubertal children with a history of Kawasaki disease have lower aerobic capacity and peak exercise tolerance than healthy peers, particularly males, highlighting the need for regular exercise to maintain cardiopulmonary health.

Cite This Study

Lu et al. (2025) studied this question.

synapsesocial.com/papers/6a7df072603f5e16dd33aeebhttps://doi.org/10.1016/j.clinsp.2025.100773
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Patients with Kawasaki Disease Have Significantly Low Aerobic Metabolism Capacity and Peak Exercise Load Capacity during Adolescence2020 · 14 citations
  2. 2Serial Exercise Testing and Echocardiography Findings of Patients With Kawasaki Disease2022 · 9 citations
  3. 3Exercise tolerance test in Kawasaki patients without coronary lesions2026
  4. 4Cardiopulmonary Function, Exercise Capacity, and Echocardiography Finding of Pediatric Patients With Kawasaki Disease2016 · 18 citations
  5. 5Midterm comprehensive cardiovascular assessment of patients with Kawasaki disease2025 · 2 citations