Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 27, 2026Cardiology in the Young

Pediatric Kawasaki disease with aneurysms shows no difference in exercise-induced systolic and diastolic indices versus controls.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Kawasaki disease may cause coronary artery aneurysms and long-term myocardial dysfunction, but data comparing exercise responses using contemporary coronary risk stratification are limited.

Does exercise stress echocardiography reveal differences in myocardial function reserve in paediatric patients with Kawasaki disease compared to controls?

Population

34 Kawasaki disease patients with coronary aneurysms and 27 age-matched controls

Comparison

Kawasaki disease with coronary artery aneurysm vs age-matched controls without cardiac disease

Design

Retrospective study

Key result

Paediatric patients with a history of Kawasaki disease and coronary aneurysms showed no significant differences in exercise-induced changes in systolic and diastolic indices compared to controls.

Authors

AWAlan WangCPCassandra PolsenCLChristina Laternser

Discussion

Loading...

Member takes

Overview

Adds retrospective exercise reserve data in Kawasaki disease by risk stratum; leaves open prospective validation before guiding surveillance.

Key Points

  • To evaluate systolic and diastolic myocardial reserve using exercise stress echocardiography in paediatric patients with a history of Kawasaki disease-associated coronary artery aneurysms compared to healthy controls.
  • Retrospectively analyzed exercise stress echocardiograms from 34 paediatric patients with Kawasaki disease-related coronary artery aneurysms (maximum z-score ≥2.5, mean 3.8 ± 2.1) and 27 age-matched controls.
  • Measured left ventricular strain, left atrial strain, and mitral inflow velocities at rest and early recovery after standardized ergometer exercise.
  • Assessed within-group changes using paired t-tests and compared the magnitude of exercise-induced response between groups via linear mixed-effects models.
  • Both cohorts showed significant pre- to post-exercise increases in left ventricular longitudinal strain and mitral A velocity, alongside additional systolic and diastolic parameter changes in the Kawasaki disease group.
  • Linear mixed-effects models revealed no statistically significant differences in the magnitude of exercise-induced systolic and diastolic parameter changes between Kawasaki disease patients (N=34) and controls (N=27).

Study Design

Type

Case-Control (n=61)

Structured PICO

Does exercise stress echocardiography reveal differences in myocardial function reserve in paediatric patients with Kawasaki disease compared to controls?

P
Population
61 paediatric patients, comprising 34 with a history of Kawasaki disease-related coronary artery aneurysm and 27 age-matched healthy controls, evaluated with exercise stress echocardiography.
E
Exposure
Exercise stress echocardiography (standardised ergometer exercise test) with two-dimensional echocardiography performed at rest and during early recovery.
C
Comparator
Age-matched controls without cardiac disease undergoing the same exercise stress echocardiography protocol.
O
Outcome
Magnitude of exercise-induced change in systolic and diastolic indices (left ventricular and left atrial strain and mitral inflow velocities).surrogate

Paediatric patients with a history of Kawasaki disease and mild to moderate coronary artery aneurysms show preserved systolic and diastolic reserve on exercise stress echocardiography comparable to healthy controls.

Cite This Study

Wang et al. (2026) conducted a case-control in Kawasaki disease (n=61). History of Kawasaki disease-related coronary artery aneurysm vs. Age-matched controls without cardiac disease was evaluated on Magnitude of exercise-induced change in systolic and diastolic indices (left ventricular and left atrial strain and mitral inflow velocities). Paediatric patients with a history of Kawasaki disease and coronary aneurysms showed no significant differences in exercise-induced changes in systolic and diastolic indices compared to controls.

synapsesocial.com/papers/6a8fe9c910c91c1e92621b5dhttps://doi.org/10.1017/s1047951126123786
View Full Paper
Ask AI
Bookmark
Share