Why the study?
Does KB-R7943 reduce arrhythmogenic activity and prevent ouabain-induced arrhythmogenicity in isolated rabbit pulmonary vein tissues?
Does KB-R7943 reduce arrhythmogenic activity and prevent ouabain-induced arrhythmogenicity in isolated rabbit pulmonary vein tissues?
Inhibition of the Na+/Ca2+ exchanger with KB-R7943 reduces pulmonary vein arrhythmogenic activity and prevents ouabain-induced arrhythmogenicity, highlighting the role of NCX current in atrial fibrillation triggers.
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Should not yet alter AF management; leaves open NCX inhibition as a target for future translational studies.
Wongcharoen et al. (2006) studied this question.
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