December 16, 2010Cell CalciumOpen Access

Inhibition of spontaneous activity of rabbit atrioventricular node cells by KB-R7943 and inhibitors of sarcoplasmic reticulum Ca2+ ATPase

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Population

Cells isolated from the rabbit atrioventricular node (AVN)

Design

Preclinical

Authors

HCHongwei ChengUniversity of Bristol GSGodfrey L. SmithElectrophysiology JHJules C. HancoxElectrophysiology

Discussion

Member takes

Implication

Supports SR Ca release role in rabbit AVN automaticity; leaves open human relevance or therapeutic targeting.

Structured PICO

Population

Cells isolated from the rabbit atrioventricular node (AVN)

Intervention

Na-Ca exchange (NCX) inhibitor KB-R7943 (5 μM), or sarcoplasmic reticulum calcium ATPase (SERCA) inhibitors thapsigargin (2.5 μM) or cyclopiazonic acid (30 μM)

Outcome

Spontaneous action potentials (APs) and intracellular calcium ([Ca(2+)](i)) transientssurrogate

Sarcoplasmic reticulum calcium release influences spontaneous activity in rabbit AVN cells via calcium-activated NCX current, though the NCX inhibitor KB-R7943 also inhibits L-type calcium current.

Cite This Study

Cheng et al. (2010) studied this question.

synapsesocial.com/papers/6a73a7e87af34f94aaa736d6 https://doi.org/10.1016/j.ceca.2010.11.008

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Inhibition of spontaneous activity of rabbit atrioventricular node cells by KB-R7943 and inhibitors of sarcoplasmic reticulum Ca2+ ATPase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Inhibition of spontaneous activity of rabbit atrioventricular node cells by KB-R7943 and inhibitors of sarcoplasmic reticulum Ca2+ ATPase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider