Population
Transgenic mice that express rat tonin (TGM(rTon)) and their wild-type (WT) littermates
Comparison
Expression of rat tonin (transgenic model) vs Wild-type (WT) littermates
Design
Preclinical
Authors
Loading...
Tonin may modulate renal RAS in rodents; leaves open relevance to human ACE regulation or hypertension.
In a transgenic mouse model, abundance of rat tonin increases N-domain ACE activity and alters the renal renin-angiotensin system.
Ribeiro et al. (2015) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: