September 9, 2003CirculationOpen Access

Dual Inhibition of β-Adrenergic and Angiotensin II Receptors by a Single Antagonist

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Population

Mouse cardiomyocytes and intact mice

Design

Preclinical

Authors

LBLiza Barki‐HarringtonUniversity of Haifa LLLouis M. LuttrellMedical University of South Carolina HRHoward A. RockmanHeart Failure & Transplant

Discussion

Member takes

Implication

Should not alter beta-blocker or ARB use in patients; leaves open translation of receptor crosstalk to human disease.

Structured PICO

Population

Mouse cardiomyocytes and intact mice

Intervention

Selective blockade of beta-adrenergic receptors and administration of valsartan

Outcome

Angiotensin-induced contractility and catecholamine-induced elevation of heart ratesurrogate

Demonstrates a direct functional interaction between beta-adrenergic and angiotensin II type 1 receptors, where a single antagonist can inhibit signaling of both.

Cite This Study

Barki‐Harrington et al. (2003) studied this question.

synapsesocial.com/papers/6a8cfe6b1af30e2244eaa6c6 https://doi.org/10.1161/01.cir.0000092166.30360.78

View Full Paper

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Dual Inhibition of β-Adrenergic and Angiotensin II Receptors by a Single Antagonist

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Dual Inhibition of β-Adrenergic and Angiotensin II Receptors by a Single Antagonist

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider