March 1, 1998Hypertension
Effects of Angiotensin II Type 1 Receptor Blockade and Angiotensin-Converting Enzyme Inhibition on Cardiac β-Adrenergic Signal Transduction
Why the study?
Does captopril or Bay 10-6734 improve cardiac beta-adrenergic signal transduction in a transgenic rat model of renin-induced hypertension?
Population
Transgenic rats harboring the mouse renin 2d gene [TG(mREN2)27] with renin-induced hypertension
Comparison
Captopril or AT1-antagonist Bay 10-6734 vs Untreated transgenic rats
Design
Preclinical
Authors
Discussion
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Member takes
Implication
No practice change indicated from animal data; leaves open mechanistic translation of RAS inhibition to human HF.
Structured PICO
Does captopril or Bay 10-6734 improve cardiac beta-adrenergic signal transduction in a transgenic rat model of renin-induced hypertension?
P
Population
Transgenic rats harboring the mouse renin 2d gene [TG(mREN2)27] with renin-induced hypertension
I
Intervention
Captopril (100 mg/kg of feed) or AT1-antagonist Bay 10-6734 (100 mg/kg of feed)
C
Comparator
Untreated transgenic rats
O
Outcome
Cardiac beta-adrenergic signal transduction components (neuropeptide Y, angiotensin II levels, adenylyl cyclase activity, beta-adrenergic receptors, G(salpha), and G(ialpha))surrogate
Pharmacological inhibition of the renin-angiotensin system reverses local sympathetic neuroeffector defects in a hypertensive rat model, providing mechanistic insight into their benefits in heart failure.
Cite This Study
Böhm et al. (1998) studied this question.