Why the study?
Does oral administration of nifedipine, nisoldipine, or niludipine reduce early ventricular arrhythmias resulting from acute myocardial ischemia in rats?
Does oral administration of nifedipine, nisoldipine, or niludipine reduce early ventricular arrhythmias resulting from acute myocardial ischemia in rats?
Oral administration of calcium antagonists prior to acute coronary ligation in rats significantly reduces the duration of life-threatening ventricular arrhythmias and prevents early mortality.
Should not yet change practice in acute MI; leaves open translation of calcium antagonist effects to human ventricular arrhythmias.
The oral administration to rats of the calcium antagonists nifedipine, nisoldipine and niludipine (3 mg/kg, 1-1.25 h before acute coronary ligation) greatly reduced the duration of ventricular tachycardia and fibrillation (VF) occurring in the first 30 min post-ligation period. The duration of VF was especially reduced (by 74-92%). None of the animals so treated died compared with a 40% mortality in the controls.
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Fagbemi et al. (1981) studied this question.
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