Why the study?
Do prostaglandins affect late coronary ligation arrhythmias in a dog model?
Do prostaglandins affect late coronary ligation arrhythmias in a dog model?
Endogenous and exogenous prostaglandins do not appear to play a significant role in the genesis of late coronary ligation arrhythmias in dogs.
Prostaglandins do not modulate late coronary ligation arrhythmias in dogs; leaves open their role in other species or human substrates.
Effects of an intravenous injection of indomethacin, prostaglandins (PGs) E1, E2 and F2 alpha and prostacyclin were examined by the use of a model of two-stage coronary ligation arrhythmias in conscious dogs. Indomethacin had no effect on the arrhythmias occurring 48 hr after coronary ligation. PGs and prostacyclin were injected after the injection of indomethacin. PGs did not show any significant antiarrhythmic effects on the arrhythmias occurring 48 hr after coronary ligation, while prostacyclin showed a transient arrhythmogenic effect. From the foregoing results, both endogenous and exogenous PGs do not seem to play a significant role in the genesis of late coronary ligation arrhythmias in the dog.
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Hashimoto et al. (1983) studied this question.
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