Why the study?
Does lidocaine or diltiazem alter electrophysiologic parameters and arrhythmias in acutely ischemic porcine myocardium?
Population
Open-chest anesthetized pigs with acute myocardial ischemia induced by 6-minute left anterior descending…
Comparison
Injection of lidocaine or diltiazem vs Control conditions
Design
Preclinical
Authors
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Should not yet change practice in acute ischemia; hypothesis-generating for diltiazem's protective effects in humans.
Does lidocaine or diltiazem alter electrophysiologic parameters and arrhythmias in acutely ischemic porcine myocardium?
In a porcine model of acute ischemia, diltiazem prevents ischemic electrophysiologic alterations and arrhythmias, whereas lidocaine exacerbates them.
Cardinal et al. (1989) studied this question.
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