Why the study?
Does disopyramide phosphate infusion affect the ventricular fibrillation threshold in normal and ischemic dog ventricles?
Does disopyramide phosphate infusion affect the ventricular fibrillation threshold in normal and ischemic dog ventricles?
Answers are grounded in this paper and cite their sources.
Disopyramide phosphate increases the ventricular fibrillation threshold in both normal and ischemic canine ventricles, likely via an anticholinergic mechanism.
The effect of disopyramide phosphate (DP) infusion (1 mg/Kg and 2 mg/Kg BW) on ventricular fibrillation threshold (VFT) was studied in anesthetized dogs. In the 1 mg/Kg group, the VFT increased 47% above the control level immediately after infusion. In the 2 mg/Kg group, a delayed increase in VFT was observed after the initial period and VFT was not correlated with the plasma concentration of DP. This phenomenon was abolished by pretreatment with methacholine. These results suggested an anticholinergic action of DP on the VFT. In the ischemic dogs produced by acute coronary occlusion, DP prevented a decrease in VFT.
No takes yet. Share an insight, caveat, or question.
Tajima et al. (1983) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: