Why the study?
Does encainide, lorcainide, or ORG 6001 improve ventricular fibrillation thresholds compared to lignocaine in isolated rabbit and guinea-pig hearts?
Population
Isolated Langendorff-perfused rabbit and guinea-pig hearts
Comparison
Perfusion with encainide, lorcainide, or ORG 6001 vs Perfusion with lignocaine
Design
Preclinical
Authors
Loading...
These animal data are hypothesis-generating; leaves open translation to clinical VF prevention.
Does encainide, lorcainide, or ORG 6001 improve ventricular fibrillation thresholds compared to lignocaine in isolated rabbit and guinea-pig hearts?
Encainide, lorcainide, and ORG 6001 demonstrate significant antifibrillatory activity in isolated animal hearts, with lorcainide showing the highest potency and complete protection against ouabain-induced fibrillation.
Almotrefi et al. (1981) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: