What question did this study set out to answer?

This research examines the effectiveness of a new agent, SR 33589, in comparison to standard treatments for ischemia-induced ventricular arrhythmias.

October 1, 1995Journal of Cardiovascular Pharmacology

Effects of a New Amiodarone-Like Agent, SR 33589, in Comparison to Amiodarone, D,L-Sotalol, and Lignocaine, on Ischemia-Induced Ventricular Arrhythmias in Anesthetized Pigs

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Why the study?

Does SR 33589 reduce the incidence of ischemia-induced ventricular arrhythmias compared to amiodarone, sotalol, and lignocaine in anesthetized pigs?

Population

Anesthetized pigs with ischemia induced by occlusion of the left coronary descending artery (LAD) for 30 min

Comparison

SR 33589 (1.25, 2.50, and 5 mg/kg intravenously) vs Control group, amiodarone, D,L-sotalol, and…

Design

Preclinical

Follow-up

30 min

Authors

OFOlivier FinanceWestern University AMA ManningSt Thomas' Hospital PCPierre ChatelainUniversité Claude Bernard Lyon 1

Discussion

Member takes

Implication

Hypothesis-generating for SR 33589 in porcine ischemia-induced VF; clinical translation untested and should not change practice.

Key Points

This research examines the effectiveness of a new agent, SR 33589, in comparison to standard treatments for ischemia-induced ventricular arrhythmias.
Twenty anesthetized pigs underwent induced ischemia via left coronary artery occlusion for 30 minutes.
Subjects were treated with varying doses of SR 33589, amiodarone, D,L-sotalol, or lignocaine during the procedure.
Ventricular arrhythmias including VF, VT, and PVCs were recorded and analyzed for incidence and severity.
SR 33589 reduced VF incidence from 90% to 30% (p < 0.05) at 1.25 mg/kg, to 10% (p < 0.001) at 2.50 mg/kg, and to 20% (p < 0.01) at 5 mg/kg.
Amiodarone showed VF reductions of 40% and 50% at doses of 10 and 20 mg/kg, respectively, without statistical significance.
D,L-sotalol decreased VF incidence by 20% (p < 0.01), while lignocaine showed no anti-arrhythmic effects.

Structured PICO

Does SR 33589 reduce the incidence of ischemia-induced ventricular arrhythmias compared to amiodarone, sotalol, and lignocaine in anesthetized pigs?

Population

Anesthetized pigs with ischemia induced by occlusion of the left coronary descending artery (LAD) for 30 min

Intervention

SR 33589 (1.25, 2.50, and 5 mg/kg intravenously)

Comparator

Control group, amiodarone (10 and 20 mg/kg i.v.), D,L-sotalol (3 mg/kg i.v.), and lignocaine (2-mg/kg bolus followed by 70 micrograms/kg/min infusion)

Outcome

Incidence of ventricular fibrillation (VF) during 30 min of coronary occlusionsurrogate

The new amiodarone-like agent SR 33589 significantly reduced ischemia-induced ventricular fibrillation and arrhythmias in a porcine model.

Cite This Study

Finance et al. (1995) studied this question.

synapsesocial.com/papers/6a6f4e1a8031ec7bb1dbb114 https://doi.org/10.1097/00005344-199510000-00010

Topics

Ventricular arrhythmias Women and heart disease

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Effects of a New Amiodarone-Like Agent, SR 33589, in Comparison to Amiodarone, D,L-Sotalol, and Lignocaine, on Ischemia-Induced Ventricular Arrhythmias in Anesthetized Pigs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Effects of a New Amiodarone-Like Agent, SR 33589, in Comparison to Amiodarone, D,L-Sotalol, and Lignocaine, on Ischemia-Induced Ventricular Arrhythmias in Anesthetized Pigs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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