What question did this study set out to answer?

To compare the electrophysiological effects of SR 33589 with those of amiodarone. The aim is to assess the potential of SR 33589 as an effective antiarrhythmic agent.

February 1, 1995Journal of Cardiovascular Pharmacology

SR 33589, a New Amiodarone-like Antiarrhythmic Agent

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Why the study?

Does SR 33589 produce similar electrophysiological effects to amiodarone in anesthetized dogs?

Population

Mongrel dogs anesthetized with chloralose

Comparison

SR 33589 administered intravenously at 1, 2.5… vs Amiodarone 5 mg/kg administered intravenously…

Design

Preclinical

Follow-up

acute (60 minutes between doses)

Authors

AMA ManningSt Thomas' Hospital VTVincent ThisseSanofi (Belgium)DHDominique HodeigeUCLouvain

Discussion

Member takes

Implication

SR 33589 shows amiodarone-like effects in dogs; leaves open translation to human antiarrhythmic use.

Key Points

To compare the electrophysiological effects of SR 33589 with those of amiodarone. The aim is to assess the potential of SR 33589 as an effective antiarrhythmic agent.
Anesthetized mongrel dogs were used for the study.
Electrodes were implanted in the right atrium and ventricle for measurements.
SR 33589 and amiodarone were administered intravenously at varying doses, followed by electrical tests.
SR 33589 (2.5 mg/kg) reduced heart rate by 21% (p < 0.001) and prolonged various refractory periods, notably increasing the atrioventricular node effective refractory period by 63% (p < 0.01).
Amiodarone reduced heart rate by 19% (p < 0.05) and similarly impacted refractory periods with less net change in PQ intervals.
Both agents showed increased effects at higher doses, with SR 33589 demonstrating less reduction in effects at shorter cycle lengths compared to amiodarone.

Structured PICO

Does SR 33589 produce similar electrophysiological effects to amiodarone in anesthetized dogs?

Population

Mongrel dogs anesthetized with chloralose

Intervention

SR 33589 administered intravenously at 1, 2.5, or 5 mg/kg followed 60 min later by a second similar dose

Comparator

Amiodarone 5 mg/kg administered intravenously followed 60 min later by a second similar dose

Outcome

Electrophysiological effects including sinus cycle length, AH interval, Wenckebach cycle length, atrial, atrioventricular node, and ventricular effective refractory periods, and surface ECG parameterssurrogate

Acute administration of the new agent SR 33589 produces electrophysiological actions similar to those of amiodarone in a canine model.

Cite This Study

Manning et al. (1995) studied this question.

synapsesocial.com/papers/6a6f4e1a8031ec7bb1dbb115 https://doi.org/10.1097/00005344-199502000-00010

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SR 33589, a New Amiodarone-like Antiarrhythmic Agent

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

SR 33589, a New Amiodarone-like Antiarrhythmic Agent

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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