Population
Normal and dystrophic chicken muscle
Comparison
Examination of myosin heavy chain isoforms using… vs Normal chicken muscle
Design
Preclinical
Authors
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Indicates myosin switching defects in avian dystrophy models; leaves open relevance to human disease and therapeutic targeting.
Muscular dystrophy in chickens inhibits the normal myosin gene switching that occurs during muscle maturation, leading to continued expression of neonatal myosin heavy chain in adult muscle.
Everett Bandman (1985) studied this question.
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