December 1, 2002Lipids
The types of circulating fatty acids influence vascular reactivity
Why the study?
Does a diet rich in unsaturated fatty acids alter vascular reactivity compared to a saturated fat diet in middle-aged subjects?
Population
75 middle-aged subjects (56 in a cross-sectional protocol and 19 in an intervention protocol)
Comparison
Rapeseed oil-based diet rich in mono- and… vs Control diet rich in saturated fatty acids for 4…
Design
Other
Follow-up
4 weeks per diet period
Authors
Discussion
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Implication
Saturated fat intake was associated with higher FBF; leaves open whether unsaturated fats alter vascular reactivity in middle-aged adults.
Structured PICO
Does a diet rich in unsaturated fatty acids alter vascular reactivity compared to a saturated fat diet in middle-aged subjects?
P
Population
75 middle-aged subjects (56 in a cross-sectional protocol and 19 in an intervention protocol)
I
Intervention
Rapeseed oil-based diet rich in mono- and polyunsaturated fatty acids for 4 weeks
C
Comparator
Control diet rich in saturated fatty acids for 4 weeks (crossover design separated by a 4-week washout period)
O
Outcome
Vascular reactivity measured by forearm blood flow (FBF) with venous occlusion plethysmography during hyperemiasurrogate
The composition of serum fatty acids, reflecting dietary fat intake, significantly influences vascular reactivity, with saturated fats increasing resting and hyperemic forearm blood flow compared to unsaturated fats.
Cite This Study
Lind et al. (2002) studied this question.