Heredity in Ankylosing Spondylitis

Article1 May 1959HEREDITY IN ANKYLOSING SPONDYLITISDANIEL O'CONNELL, M.D., F.F.R.DANIEL O'CONNELL, M.D., F.F.R.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-50-5-1115 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAs far as is known, the first workers to indicate a hereditary influence in ankylosing spondylitis were the members of the Clinical Club in 1888. Both Sir Jonathan Hutchinson and Alexander Morrison stressed the significance of a family history of rheumatism or gout. Later the adjective "heredo-traumatique" was applied to von Bechterew's syndrome, and Marie and Astié in 18971reported a sister and father who had had a similar disease. Geilinger in 19182thought that heredity played a part in approximately 10% of cases, but interest in this aspect of the disease waned, apart from sporadic reports of involvement of...Bibliography1. MarieAstié PC: Sur un cas de cyphose hérédotraumatique, Presse méd. 2: 205, 1897. Google Scholar2. Geilinger W: Beitrag zur Lehre von der ankylosierenden Spondylitis mit besonderer Berücksichtigung ihrer Beziehungen zur Spondylitis deformans, Ztschr. f. orthop. Chir. 38: 183, 1918. Google Scholar3. Scott SG: Monograph on adolescent spondylitis or ankylosing spondylitis, 1st Ed., 1942, Oxford University Press, London. Google Scholar4. RogoffFreyberg BRH (a) : Family incidence of rheumatoid spondylitis, Ann. Rheumat. Dis. 7: 40 1948. (b) Rogoff, B., and Freyberg, R. H.: The familial incidence of rheumatoid spondylitis, Ann. Rheumat. Dis. 8: 139, 1949. MedlineGoogle Scholar5. West HF: Aetiology of ankylosing spondylitis, Ann. Rheumat. Dis. 8: 143, 1949. CrossrefMedlineGoogle Scholar6. StecherHersh RNAH: Familial occurrences of ankylosing spondylitis, Brit. J. Phys. Med. 18: 176, 1955. MedlineGoogle Scholar7. Potter TA: Rheumatoid spondylitis (Strümpell-Marie arthritis), Am. Pract. and Digest Treat. 1: 1129, 1950. MedlineGoogle Scholar8. StephensNunemaker FEJC: Spondylitis in identical twins reared apart, J. Hered. 41: 283, 1950. CrossrefGoogle Scholar9. HershStecherSolomonWolpawHause AHRMWMRH: Heredity in ankylosing spondylitis; a study of 50 families, Am. J. Human Genet. 2: 391, 1950. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: London, England*Received for publication September 22, 1958.From the Charing Cross Hospital, London, England.Requests for reprints should be addressed to Daniel O'Connell, M.D., Charing Cross Hospital, London, W.C.2, England. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySex ratios and hormones in HLA related rheumatic diseases.Selection against genetic defects in semen donorsSpondylitis ankylosansAnkylosing Spondylitis in a Large Kindred: Clinical and Genetic StudiesSpondylitis Ankylopoetica. Die sogenannte Bechterewsche Krankheit und ihre Differentialdiagnose (einschließlich Spondylosis hyperostotica, Spondylitis psoriatica und chronisches Reiter-Syndrom)Genetics of ankylosing spondylitis.Heberden Oration, 1963 : The Epidemiology of Rheumatic DiseasesRheumatism and Arthritis Review of American and English Literature of Recent Years (Fourteenth Rheumatism Review)CHARLEY J. SMYTH, M.D., F.A.C.P., ROGER L. BLACK, M.D., CHARLES L. CHRISTIAN, M.D., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., EDWARD C. FRANKLIN, M.D., DONALD F. HILL, M.D., F.A.C.P., JOSEPH L. HOLLANDER, M.D., F.A.C.P., HOWARD L. HOLLEY, M.D., F.A.C.P., JOHN G. MAYNE, M.D., WILLIAM M. MIKKELSEN, M.D., CHARLES L. SHORT, M.D., F.A.C.P., HUGH A. SMYTHE, M.D., F.R.C.P.(C), OTTO STEINBROCKER, M.D., HOWARD J. WEINBERGER, M.D.A family study of rheumatoid (ankylosing) spondylitisMedical genetics 1959 1 May 1959Volume 50, Issue 5Page: 1115-1121KeywordsAnkylosing spondylitisArthritisGeneticsGoutHereditySpondylitis ePublished: 1 December 2008 Issue Published: 1 May 1959 PDF downloadLoading ...