December 24, 2009Endocrinology
Minireview: Delivering the Code: Polyplex Carriers for Deoxyribonucleic Acid and Ribonucleic Acid Interference Therapies
Design
Review
Authors
Discussion
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Member takes
Implication
May guide nucleic acid delivery research; leaves open clinical translation without prospective validation.
Structured PICO
I
Intervention
Polyplex carriers for DNA and RNA interference therapies
Synthetic polymers forming ionic complexes with nucleic acids offer promising designs to overcome delivery barriers such as circulation stability and endosomal escape for DNA and RNA therapies.
Cite This Study
Christie et al. (2009) studied this question.