What question did this study set out to answer?

To review polymeric micellar delivery systems that overcome cellular and extracellular barriers hindering nucleic acid therapeutics in advanced solid tumors.

November 9, 2025Materials & DesignOpen Access

Micelleplex nucleic acid delivery systems: Overcoming barriers for treatment of advanced solid tumors

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Authors

ADAbolfazl DoustmihanTabriz University of Medical Sciences MAMorteza AkbariIsfahan University of Medical Sciences MJMehdi JaymandKermanshah University of Medical Sciences

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Implication

Review reveals micelleplex polymeric platforms improve nucleic acid delivery in advanced solid tumors, highlighting versatile strategies to overcome cellular barriers and enhance therapeutic...

Key Points

To review polymeric micellar delivery systems that overcome cellular and extracellular barriers hindering nucleic acid therapeutics in advanced solid tumors.
Synthesized recent advances in polymeric micellar nanotechnology designed to encapsulate, protect, and transport therapeutic nucleic acids.
Evaluated critical physicochemical attributes and mechanisms, including thermodynamic stability, endosomal escape, cellular membrane interaction, and dual-delivery with chemotherapeutics.
Polymeric micellar complexes safeguard nucleic acids from enzymatic breakdown, markedly extending blood circulation time and enhancing serum stability.
Micellar carriers facilitate endosomal escape and cellular uptake, achieving elevated transfection efficiency and gene silencing with minimal in vitro cytotoxicity and reduced immune activation.

Cite This Study

Doustmihan et al. (2025) studied this question.

synapsesocial.com/papers/6a156f0a814bf8ec9a4e9590 https://doi.org/10.1016/j.matdes.2025.115098

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Implication

Review reveals micelleplex polymeric platforms improve nucleic acid delivery in advanced solid tumors, highlighting versatile strategies to overcome cellular barriers and enhance therapeutic...

Micelleplex nucleic acid delivery systems: Overcoming barriers for treatment of advanced solid tumors

Discussion

Member takes

Implication

Key Points

Cite This Study

Micelleplex nucleic acid delivery systems: Overcoming barriers for treatment of advanced solid tumors

Discussion

Member takes

Implication

Key Points

Cite This Study

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