Why the study?
Does platelet-derived growth factor (PDGF)-BB increase the synthesis of lipoprotein lipase in human monocyte-derived macrophages?
Population
Human monocyte-derived macrophages
Comparison
Platelet-derived growth factor-BB cultured for 8… vs Untreated macrophages (implied control)
Design
Preclinical
Follow-up
8 days
Authors
Loading...
PDGF-BB may modulate macrophage lipid handling via PKC; leaves open its role in human atherosclerosis.
Does platelet-derived growth factor (PDGF)-BB increase the synthesis of lipoprotein lipase in human monocyte-derived macrophages?
PDGF-BB stimulates transcription of the LPL gene in human monocyte-derived macrophages via protein kinase C activation, suggesting a mechanism by which it may modulate atherosclerosis.
Inaba et al. (1995) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: