The influence of oxidatively modified low density lipoproteins on expression of platelet-derived growth factor by human monocyte-derived macrophages
Why the study?
Does exposure to oxidatively modified LDL alter PDGF expression and secretion in human monocyte-derived macrophages?
Population
Adherent cultures of human blood monocyte-derived macrophages
Comparison
Oxidatively modified low density lipoproteins vs Acetylated LDL, LDL aggregates, or basal…
Design
Preclinical
Follow-up
2 hours
Authors
Discussion
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Member takes
Implication
Oxidized LDL may suppress macrophage PDGF in atherogenesis; leaves open effects on plaque progression.
Structured PICO
Does exposure to oxidatively modified LDL alter PDGF expression and secretion in human monocyte-derived macrophages?
P
Population
Adherent cultures of human blood monocyte-derived macrophages
I
Intervention
Oxidatively modified low density lipoproteins (LDL)
C
Comparator
Acetylated LDL, LDL aggregates, or basal conditions
O
Outcome
PDGF gene expression (PDGF-B mRNA), synthesis, and secretionsurrogate
Uptake of oxidatively modified LDL inhibits PDGF expression and secretion in human macrophages, which may influence smooth muscle cell behavior during atherogenesis.
Cite This Study
Malden et al. (1991) studied this question.