Why the study?
Do direct renin inhibitors improve surrogate markers of renal and cardiovascular function in preclinical and clinical studies?
Do direct renin inhibitors improve surrogate markers of renal and cardiovascular function in preclinical and clinical studies?
Direct renin inhibitors demonstrate favorable effects on surrogate markers of renal and cardiovascular function, suggesting potential organ-protective benefits beyond blood pressure lowering.
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DRIs match RAAS inhibitors on renal-CV surrogates and lower BNP in HF; extends class effects to direct renin blockade on hemodynamics.
Heerspink et al. (2009) studied this question.
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