Why the study?
Does direct renin inhibitor administration induce proliferative changes in afferent arteriolar walls in spontaneous hypertensive rats?
Does direct renin inhibitor administration induce proliferative changes in afferent arteriolar walls in spontaneous hypertensive rats?
In a rat model of hypertension, long-term direct renin inhibitor administration increased tissue renin but did not induce the afferent arteriolar proliferative changes previously seen with ARBs.
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No afferent arteriolar proliferation with DRI despite increased renin in hypertensive rats; leaves open differential effects versus ARBs for human translation.
Nagai et al. (2016) studied this question.
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