Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 1, 1976American Journal of Physiology-Legacy Content

Rigor and resistance to stretch in vertebrate smooth muscle

View Full Paper
Ask AI
Bookmark
Share

Population

Rabbit taenia coli muscle

Comparison

Depletion of ATP content to 0.07 mumol/g in… vs Calcium-free solution and resting state

Design

Preclinical

Authors

BTButler TmThomas Jefferson UniversityMSMJ SiegmanThomas Jefferson UniversityDRDavies ReUniversity Hospital of Wales

Discussion

Loading...

Member takes

Overview

ATP depletion may trigger calcium-dependent rigor in smooth muscle; leaves open relevance to human vascular tone or disease.

Structured PICO

P
Population
Rabbit taenia coli muscle
I
Intervention
Depletion of ATP content to 0.07 mumol/g in calcium-containing Krebs solution at 21 degrees C
C
Comparator
Calcium-free solution and resting state
O
Outcome
Force and resistance to stretchsurrogate

The study demonstrates that a rigor state exists in vertebrate smooth muscle, characterized by increased force and stiffness upon ATP depletion in the presence of calcium.

Cite This Study

Tm et al. (1976) studied this question.

synapsesocial.com/papers/6a8d1a0dd34831cc2b09a12ehttps://doi.org/10.1152/ajplegacy.1976.231.5.1509
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Force response to rapid length change during contraction and rigor in skinned smooth muscle of guinea‐pig taenia coli.1991 · 14 citations
  2. 2Crossbridge Attachment, Resistance to Stretch, and Viscoelasticity in Resting Mammalian Smooth Muscle1976 · 56 citations
  3. 3Basis of passive tension and stiffness in isolated rabbit myofibrils1997 · 96 citations
  4. 4Thin filament regulation of force activation is not essential in single vascular smooth muscle cells1995 · 22 citations
  5. 5Stiffness of active smooth muscle during forced elongation1987 · 11 citations