Population
Rabbit intrarenal arterial vasculature from chronic two-kidney, one clip Goldblatt hypertensive rabbits and…
Comparison
Characterization of alpha-adrenergic receptor… vs Age-matched sham-operated normotensive control…
Design
Preclinical
Follow-up
12 weeks
Authors
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Warrants investigation of alpha1-adrenergic changes in human renovascular hypertension; leaves open clinical relevance.
The study demonstrates the presence of alpha 1- and alpha 2-adrenergic receptors in rabbit intrarenal arteries and shows transient increases in alpha 1-receptor affinity during the development of renovascular hypertension.
McElroy et al. (1989) studied this question.
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