Key result
Neurally-induced vasoconstriction in the rabbit knee joint capsule is mediated predominantly by postjunctional alpha 2-adrenoceptors, contrasting with previous in vitro findings.
Population
Blood vessels in the posterior region of the rabbit knee joint capsule (in vivo model)
Comparison
Electrical stimulation of the posterior… vs Control responses
Design
Preclinical
Authors
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Alpha2 predominance in rabbit joint vasoconstriction; leaves open translation to human joint physiology or therapy.
In vivo vasoconstriction in rabbit knee joint blood vessels is mediated predominantly by postjunctional alpha 2-adrenoceptors, contrasting with previous in vitro findings of alpha 1-adrenoceptor dominance.
Najafipour et al. (1993) studied this question. Electrical stimulation and alpha-adrenoceptor agonists/antagonists was evaluated on Neurally-induced vasoconstriction. Neurally-induced vasoconstriction in the rabbit knee joint capsule is mediated predominantly by postjunctional alpha 2-adrenoceptors, contrasting with previous in vitro findings.
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