Why the study?
Does noradrenaline infusion elicit a different pressor and vascular response in normotensive, non-obese type 2 diabetic patients compared to healthy volunteers?
Does noradrenaline infusion elicit a different pressor and vascular response in normotensive, non-obese type 2 diabetic patients compared to healthy volunteers?
Normotensive, non-obese type 2 diabetic patients exhibit an enhanced pressor response to noradrenaline that is not due to increased responsiveness in skeletal muscle resistance arterioles or peripheral veins.
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Enhanced noradrenaline pressor sensitivity in type 2 diabetes may raise hemodynamic risk; hypothesis-generating for mechanisms beyond peripheral beds and should not yet change practice.
F. C. Huvers (1998) studied this question.
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