Why the study?
Does enalapril modify the pressor responsiveness to norepinephrine in patients with type II diabetes?
Population
24 subjects
Comparison
Enalapril administered for 4 weeks vs Baseline and cross-group comparison
Design
Cohort
Follow-up
4 weeks
Authors
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Norepinephrine hyperresponsiveness persists after enalapril in type 2 diabetes; leaves open ACE-independent vascular mechanisms versus essential hypertension.
Does enalapril modify the pressor responsiveness to norepinephrine in patients with type II diabetes?
Type II diabetic patients exhibit an increased pressor responsiveness to norepinephrine that, unlike in essential hypertension, is not reversed by ACE inhibition with enalapril.
Ciavarella et al. (1994) studied this question.
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