Why the study?
Does norepinephrine infusion elicit different blood pressure, heart rate, and plasma catecholamine responses in normal subjects compared to patients with essential or renal hypertension?
Population
20 subjects, comprising 7 normal subjects and 13 patients with essential or renal hypertension
Comparison
Norepinephrine infusion at rates of 0.05, 0.1… vs Normal subjects compared to patients with…
Design
Other
Authors
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May indicate non-concentration-dependent mechanisms in hypertensive hyperresponsiveness; hypothesis-generating for vascular or baroreflex factors in larger studies.
Does norepinephrine infusion elicit different blood pressure, heart rate, and plasma catecholamine responses in normal subjects compared to patients with essential or renal hypertension?
Hyperresponsiveness to norepinephrine in some hypertensive patients is not driven by higher plasma NE concentrations, suggesting mechanisms like vascular structural alterations or diminished baroreflex sensitivity.
Manger et al. (1976) studied this question.
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