Why the study?
Does candesartan prevent the development of salt-sensitive hypertension in sensory-denervated rats?
Population
Male Wistar rats with neonatal capsaicin-induced sensory denervation (50 mg/kg s.c. on days 1 and 2 of life)
Comparison
Candesartan cilexetil combined with a high… vs Vehicle-treated controls on high sodium diet…
Design
Preclinical
Follow-up
3 weeks
Authors
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Highlights RAS role in salt-sensitive hypertension after sensory denervation; leaves open clinical translation.
Does candesartan prevent the development of salt-sensitive hypertension in sensory-denervated rats?
In a sensory-denervated rat model, abnormal regulation of the renin-angiotensin system contributes to salt-sensitive hypertension, which can be prevented by AT1-receptor blockade with candesartan.
Wang et al. (2001) studied this question.
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