February 1, 2002Hypertension

Function and Regulation of Endothelin-1 and Its Receptors in Salt Sensitive Hypertension Induced by Sensory Nerve Degeneration

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Why the study?

Does ET(A) or ET(B) receptor blockade alter blood pressure in a rat model of salt-sensitive hypertension induced by sensory nerve degeneration?

Population

Newborn Wistar rats treated with vehicle or 50 mg/kg capsaicin subcutaneously on the first and second days…

Comparison

Selective ET antagonist or ET antagonist… vs Control rats on normal or high salt diet without…

Design

Preclinical, divided into eight groups

Follow-up

2 weeks

Authors

DYDiana Z. YeUniversity of Pennsylvania DWDonna H. WangMichigan State University

Discussion

Member takes

Implication

ET(A) blockade may attenuate salt-sensitive hypertension in this model; leaves open ET(B) compensatory roles in human disease.

Structured PICO

Does ET(A) or ET(B) receptor blockade alter blood pressure in a rat model of salt-sensitive hypertension induced by sensory nerve degeneration?

Population

Newborn Wistar rats (males used after weaning) treated with vehicle or 50 mg/kg capsaicin subcutaneously on the first and second days of life to induce sensory nerve degeneration.

Intervention

Selective ET(A) antagonist (ABT-627, 5 mg/kg/d) or ET(B) antagonist (A-192621, 30 mg/kg/d) administered by oral gavage twice a day for 2 weeks, in combination with a high salt (4%) or normal salt (0.5%) diet.

Comparator

Control rats (vehicle-treated) on normal or high salt diet without antagonists, and capsaicin-treated rats on normal or high salt diet without antagonists.

Outcome

Mean arterial pressure (MAP) and ET-1 plasma concentration after 2 weeks of treatment.surrogate

In a rat model of salt-sensitive hypertension induced by sensory nerve degeneration, ET(A) receptor blockade prevents hypertension while ET(B) receptor blockade exacerbates it, suggesting ET(B) plays a compensatory antihypertensive role.

Cite This Study

Ye et al. (2002) studied this question.

synapsesocial.com/papers/6a908c77fdaee66aea8413b3 https://doi.org/10.1161/hy0202.103480

Topics

Hypertension management

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Function and Regulation of Endothelin-1 and Its Receptors in Salt Sensitive Hypertension Induced by Sensory Nerve Degeneration

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Function and Regulation of Endothelin-1 and Its Receptors in Salt Sensitive Hypertension Induced by Sensory Nerve Degeneration

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

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