Why the study?
What is the vascular versus myocardial selectivity of amlodipine, felodipine, and nifedipine in spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats
Comparison
Dihydropyridine calcium antagonists vs Comparison among amlodipine, felodipine, and…
Design
Preclinical
Authors
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May guide dihydropyridine development; leaves open clinical relevance in humans.
What is the vascular versus myocardial selectivity of amlodipine, felodipine, and nifedipine in spontaneously hypertensive rats?
Felodipine demonstrates significantly higher vascular versus myocardial selectivity compared to amlodipine and nifedipine in a rat model.
Nordlander et al. (1995) studied this question.
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