Modulation of divalent cation‐activated chloride ion currents
Population
Cultured dorsal root ganglion neurones
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Extends Cl- current regulation models in sensory neurons; hypothesis-generating with no clinical implications yet.
Structured PICO
P
Population
Cultured dorsal root ganglion neurones
I
Intervention
Extracellular application of (-)-baclofen (100 microM), Bay K 8644 (5 microM), intracellular GTP-gamma-S, and extracellular caffeine (10mM)
O
Outcome
Modulation of divalent cation-activated chloride ion currents (ICl(Ba), ICl(Ca)) and voltage-sensitive calcium channel currents (ICa, IBa)surrogate
The study demonstrates that chloride currents in dorsal root ganglion neurons are regulated by G-protein activation in addition to divalent cation entry.
Cite This Study
Scott et al. (1988) studied this question.