September 30, 2002The Journal of PhysiologyOpen Access

Activation of store‐operated channels by noradrenaline via protein kinase C in rabbit portal vein myocytes

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Population

Rabbit portal vein smooth muscle cells (myocytes)

Design

Preclinical

Authors

AAAnthony P. AlbertUniversity of East Anglia WLW. A. LargeSt George's, University of London

Discussion

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Implication

Does not alter clinical vascular management; leaves open PKC-SOC relevance in human myocytes.

Structured PICO

Population

Rabbit portal vein smooth muscle cells (myocytes)

Intervention

Noradrenaline, 1-oleoyl-acetyl-sn-glycerol (OAG), phorbol 12,13-dibutyrate (PDBu), cyclopiazonic acid (CPA), BAPTA-AM, and PKC inhibitors (chelerythrine, RO-31-8220)

Outcome

Activation of Ca(2+)-permeable store-operated channels (SOCs) measured via single channel currentssurrogate

Noradrenaline activates store-operated channels via DAG and PKC in rabbit portal vein myocytes, indicating a potentially store-independent mechanism involving phosphorylation.

Cite This Study

Albert et al. (2002) studied this question.

synapsesocial.com/papers/6a8d1cf2d881876296cf89bf https://doi.org/10.1113/jphysiol.2002.022574

View Full Paper

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Activation of store‐operated channels by noradrenaline via protein kinase C in rabbit portal vein myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Activation of store‐operated channels by noradrenaline via protein kinase C in rabbit portal vein myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider