March 1, 1955Circulation Research

Nature of the Vasodilator and Vasoconstrictor Receptors in Skeletal Muscle of the Dog

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Why the study?

Does sympathetic nerve stimulation and catecholamine injection reveal distinct vasodilator and vasoconstrictor receptors in dog skeletal muscle?

Population

Dog skeletal muscle model

Comparison

Stimulation of the lumbar sympathetic chain at… vs Responses before adrenergic blockade and atropine

Design

Preclinical

Authors

PYPaul L. YoumansAtrium Health Wake Forest Baptist HGHarold D. GreenIndiana University Bloomington ADADAM B. DENISONAtrium Health Wake Forest Baptist

Discussion

Member takes

Implication

Delineates three vasoreceptor types in canine skeletal muscle; leaves open translation to human physiology or clinical relevance.

Structured PICO

Does sympathetic nerve stimulation and catecholamine injection reveal distinct vasodilator and vasoconstrictor receptors in dog skeletal muscle?

Population

Dog skeletal muscle model

Intervention

Stimulation of the lumbar sympathetic chain at L3, L4 and L5, and intra-arterial injections of l-epinephrine and l-norepinephrine before and after progressively increasing levels of adrenergic blockade, and after atropine

Comparator

Responses before adrenergic blockade and atropine

Outcome

Femoral blood flow and arterial pressure responsessurrogate

The study identifies three distinct types of vasoreceptors in canine skeletal muscle, differentiating between innervated (constrictor and dilator) and hormonally controlled (dilator) receptors.

Cite This Study

Youmans et al. (1955) studied this question.

synapsesocial.com/papers/6a8d1cf5a658c8b40988db1a https://doi.org/10.1161/01.res.3.2.171

View Full Paper

Ask AI

Bookmark

Nature of the Vasodilator and Vasoconstrictor Receptors in Skeletal Muscle of the Dog

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Nature of the Vasodilator and Vasoconstrictor Receptors in Skeletal Muscle of the Dog

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider