Why the study?
Does GSK-3beta inhibition induce airway smooth muscle hypertrophy in human bronchial smooth muscle cells and mouse models?
Does GSK-3beta inhibition induce airway smooth muscle hypertrophy in human bronchial smooth muscle cells and mouse models?
Inhibition of the GSK-3beta/eIF2Bepsilon translational control pathway contributes to airway smooth muscle hypertrophy, providing a potential mechanistic pathway for structural changes in severe asthma.
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GSK-3beta inhibition does not yet warrant clinical targeting in asthma; hypothesis-generating in animal models, it leaves open human translation.
Deng et al. (2008) studied this question.
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