Why the study?
Does aminoguanidine improve vascular reactivity and blood pressure in spontaneously hypertensive rats?
Does aminoguanidine improve vascular reactivity and blood pressure in spontaneously hypertensive rats?
Methylglyoxal accumulation in mesenteric arteries mediates the development of hypertension in spontaneously hypertensive rats via ROS-mediated endothelial dysfunction and AT2R-mediated contraction, suggesting a potential therapeutic target.
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Aminoguanidine improves vascular reactivity in hypertensive rats; leaves open translation to human hypertension therapy.
Mukohda et al. (2012) studied this question.
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