A novel method for recording pressure-flow diagrams in intact peripheral arteries of animals allows for real-time tracking of hemodynamic changes induced by vasomotor drugs.
Supports preclinical vascular research; leaves open clinical translation pending validation.
The present authors described a new method of recording the P-F diagram. of each cardiac cycle on an intact peripheral artery. The patterns obtained by this method were almost constant under constant circulatory conditions and bore a striking similarity to those constructed from the results of previous workers. In this connexion, some considerations on the fidelity of an electromagnetic flowmeter have been given. The carotid and femoral patterns under normal conditions differ from each other, suggesting haemodynamical characteristics of respective arterial trees. It has also been illustrated that the effect of vasoconstriction or vasodilation produced by vasomotor drugs upon haemodynamics of peripheal circulation could readily be followed up by this method and increase or decrease in peripheral resistance would cause enhancement or diminution of the D V-E component or those of phase shift between P and F.
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Inouye et al. (1955) studied this question.
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