Smooth muscle phenotypic diversity is mediated through alterations in Myocardin gene splicing

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Population

Cultured porcine smooth muscle cells (SMC)

Design

Preclinical

Authors

Discussion

MYOCD ΔExon 11 may modulate porcine SMC phenotype; hypothesis-generating for vascular remodeling with no clinical implications yet.

Population

Cultured porcine smooth muscle cells (SMC)

Intervention

Small interfering RNAs (siRNA) and specific chemical inhibitors to alter MYOCD splice selection (increasing ΔExon 11 variants)

Outcome

Contractile phenotype (assessed by morphology and molecular analysis of effector genes)surrogate

MYOCD ΔExon 11 may modulate smooth muscle cell phenotype by acting as a dominant-negative repressor of contraction-related genes.

Ilagan et al. (2010) studied this question.

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