Mechanistic study reveals that YejM modulates FtsH/YciM protease activity to control LpxC levels in Escherichia coli, highlighting essential envelope proteins as antibiotic targets.
Lipid homeostasis is critical for proper envelope functions. The level of LpxC, which catalyzes the first committed step of lipopolysaccharide (LPS) synthesis, is controlled by an essential protease complex comprised of FtsH and YciM. Work carried out here suggests YejM, an essential envelope protein, plays a central role in sensing the state of LPS synthesis and controls LpxC levels by regulating the activity of FtsH/YciM. All four essential proteins are attractive targets of therapeutic development.
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Nguyen et al. (2020) studied this question.
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